krita.org/en/
Krita is a professional free and open source painting program. It is made by artists that want to see affordable art tools for everyone. It can be used for concept art, texture and matte paintings, illustrations and comics.
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Pretty sure everything is indie on itch.io but just in case you want something extra indie.
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Explore Fighting games made with Krita tagged Indie on itch.io · Upload your games made with Krita to itch.io to have them show up here.
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