www.clipstudio.net/en
A digital painting and illustration software package with a focus on comics and manga.
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Uses two-dimensional "sprites", 2D images created and used on a flat plane, as opposed to the three-dimensional models or environments found in 3D games.
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Pretty sure everything is indie on itch.io but just in case you want something extra indie.
Explore Action games made with Clip Studio Paint tagged 2D and Indie on itch.io · Upload your games made with Clip Studio Paint to itch.io to have them show up here.
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