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Contains lesbian, gay, bisexual, and/or transgender characters or plot lines.

An otome game is a story based video game that is targeted towards the female market. Generally one of the goals, besides the main plot goal, is to develop a romantic relationship between the female player character and one of several male or female characters.

http://en.wikipedia.org/wiki/Otome_game

Yaoi, also known as boys' love, is a genre of work involving romance between men. The word originates in Japan and is typically seen alongside an anime style.