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16 pixels by 16 pixels is a common resolution for assets matching a low-res pixel art aesthetic. Although the assets may not be specifically 16x16, they are designed to work in a graphical setting where objects are around that size.

Godot Engine - The free and open source 2D and 3D game engine

Related to the process of arranging game maps using a set of tile graphics (often call tilesets)

Unity is a game engine for 2D, 3D, AR and more