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Uses two-dimensional "sprites", 2D images created and used on a flat plane, as opposed to the three-dimensional models or environments found in 3D games.

Godot Engine - The free and open source 2D and 3D game engine

Pixel Art refers to the charming, simplistic, retro/renaissance style of very-low-resolution graphics, such as from the 1977-1995 Atari, GameBoy, & Super Nintendo (SNES) eras.

Unreal Engine is a 3D game creation tool