Buenas. El juego me está gustando mucho y llevo jugando unas 40 horas. Pero tengo una pregunta. Puedo estar las rutas románticas de Despoina, Calysia y Lorena en una misma partida. Tengo esa duda por algo que vi en la wiki. ( Me gustaría saberlo para ver si seguir jugando o no ).

Hey. I read your message through translate, so I can't be 100% sure I read it correctly, but if I interpreted it right, the answer is that Calysia can only be romanced on full Moon or Midnight routes, Lorena can only be romanced on Daybreak, and Despoina can only be romanced on Twilight or Midnight. So, there is no route that has all three of them as options. In addition, any given playthrough will be able to add at most one of them to the main relationship. 

Midnight is the route on which Lorena is dead.
Full Moon is the route on which Lorena is exiled
New Moon is the route on which Lorena is accepted but Eris's deal is taken
Twilight is the route on which Lorena is accepted and another optional character she opposes is also accepted (or in which the other is dead and you take Despoina's side in Ch 15)
Daybreak is the route on which Lorena is accepted and the other optional character she opposes is exiled (dead and you side with Lorena in Chapter 15.)

Los romances de Desponia, Calysia y Lorena son exclusivos dependiendo de en que ruta estés en tu partida (Medianoche y Crepúsculo para Desponia, Luna llena y Luna nueva para Calysia y Amanecer para Lorena).