same

Ive found that if you take the Ketamine next to him you cannot speak to him.

yall r such normies playing the game how its meant to be played

You need to have no more than 5 ketamine portions on you before talking to Squidward (less may be good, I don't know). I'm not sure whether it matters if you take the one that's next to him, but from my experience whenever I've had more than those 5 portions from Patrick I just couldn't talk to him.