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Appdata -> Roaming -> Pokemon Cultivation

One of my saves got corrupted and was preventing the game from launching, so had to find it and delete the save. 

Game resized desktop resolution (zooms in a lot) and has borders all around in full screen? If so I had the same issue.

Open the game -> options -> turn fullscreen fetish off

at this point you should see a little of your desktop. Move your mouse above the game window, then lower it over the game window bar. The mouse cursor disappears, but right click anyway. 

Click properties -> Uncheck "Launch in fullscreen" -> Close and reopen the game (should be windowed, but normal now) -> options -> turn fullscreen fetish on for normal fullscreen without borders

The setting seems to be shared between some rpgmaker games, so if you check the box in another to make it fullscreen, you'll have to uncheck it again for lona. Pretty sure the setting automatically changes display resolution to 640x480 while the game is running, which is what causes the weird behavior and borders.

That patch of white seems to be the game window btw. If you move an always on top window (Like the magnifier tool) over it, it'll be gigantic and in the way when you go back to the game. 

I actually had this same thing earlier today, I dug around in my graphics settings and couldn't find a fix, then I just assumed it always had borders and I was just imagining things. Started trying to fix it again because of your post and found the problem lol. 

Open the game -> options -> turn fullscreen fetish off

at this point you should see a little of your desktop. Move your mouse above the window, then lower it over the game window bar. The mouse cursor disappears, but right click anyway. 

Click properties -> Uncheck "Launch in fullscreen" -> Close and reopen the game (should be windowed, but normal now) -> options -> turn fullscreen fetish on 

I found out that this setting seems to be universal for some rpg maker games. Specifically, I played Black Souls, which I could only fullscreen by checking this box, which is how it got checked for Lona.