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That doesn't address OPs concern at all, and I'm getting the same issue

The giantess bottle in endless mode doesn't seem to actually work when you turn that mode on.

I also had gobbo potion mode, shrinking potion, bimbonomicon, and gothnomicon active at the time, if that helps

Yeah, I'm going to have to agree here. I have no idea what the pink lines  on the completed puzzle on the left have to do with anything on the main screen. There are no lines in that shape and if there's a starting point we should be working from, like the puzzles in the yeti chapter, I'm not seeing it