Bone Riders has a quirky setting and fun procedures that have you racing across the map trying to find lore and earn money before the Trouble strikes. It's really easy to pick up and play, the rules are fun (and funny), and also based on real! life! science! (you have 206 bones).
I'm playing it solo and my little skeleton cowboy recently arrived back in town with just 6 bones left demanding whisky, after helping a conductor find his lost hat, frightening a herd of ghostly wildebeests so JJ McFish could get back to their fishing, and working a shift in the silver mines for money and gossip about the Bounty Hunter stalking the Bone Wastes.