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I did another runs with Shuckle. 

1. Rock Smash, Iron Defense, Steel Roller, Dig

I abused x-attack, shell bell and leftovers and got really good items to consistently max resistance. I also upgraded Rock Smash and Defense Curl early which carried the whole run.

Boss 8 was Dialga. By the end, I had 30 frails and even my pokes did 96 base. Boss 9 was Deoxys, and it was about the same. 

Sure, I won this time, but it felt a lot worse than other pokemon. The +2 AP, +2 MP and bonus attack were barely enough to get through early game even with x-attack. The end was also much slower than other runs. I'd compare this to my Sneasel run, where Shadow Claws were doing 250-ish on turn 1 iirc. Even with 30+ frail, that's nothing. 

I'd probably move Shuckle from F tier to low B tier, but only with Rock Smash. Frail is a terrible strat. Even if you get to 50+ frail that's not a lot of damage, and a lot of wasted time setting up. 

Pokemon Tier List 

Note: The best items are the gold boosting teeth, the x-items, everything that boosts crit and the -mana+resistance items. The worst items are the ones that gives a bunch of +3s and the red/blue orbs which are far too expensive. 

S Tier - Free Win

Mawile - Starts with a broken signature move that gives more stats than anything else in the game. Avoid stat boosting items and go all in on economy, health, resistance and crits. You can get 100% crit change by floor 5 or so. Then you just outdamage and kill everything. 

Cacnea - Can get not one, not two, but three drain moves. Need I say more? Same as above. Unkillable because you have multiple moves that heal almost your full HP bar as well as strong attacks. 

A Tier - Good. 

Marill - Cacnea but with lacking damage. My first run I got good items and won. My second run, I didn't see a single good damage boosting berry or item and died after 20 turns against Torterra. Basically a tutorial pokemon. 

Sableye - Starts with Shadow Ball and Power-Up Punch. Learns Shadow Ball (again) and Shadow Claw. SPE is such a terrible stat there's never a reason to use it. ATK and SPATK. 

Sneasel - Another crit pokemon. 100% easily. Kill everything with Shadow Claw. You can one or two turn bosses easily. 

Scyther - Sneasel but has buff moves instead of Shadow Claw. Worse over all but Fury Cutter is great. Much slower fights but still consistent. You really want a Shell Bell though. 

Croagunk - Ignore poison, get crit and strong physical moves. Win.

B Tier - Solid.  

Taillow - One of the rare SPATK pokemon. The roost double team combo isn't as good as Marill or Cacnea but is great combined with strong attacking moves. Get a shell bell and you'll win 100% of the time. 

Riolu - Surprisingly, not many great special moves. I was waiting for them to show up and they never did. Just run physical attacks and it's an okay pokemon. 

C Tier - Bad

Pikachu - The most confusing pokemon imo. I had no clue what to build into. I still don't. Just pick the best items you get and if you end up using all three stats, that's okay. Ignore the charge gimmick because it's useless. By the end of my run, I'd get 10 charges every two turns or so, which compared to the 15 energy per turn I get was useless. 

Cubone - A better debuff than poison, but still terrible. Ignore the debuff and get physical moves. Lower ranked than Croagunk because while the debuff is better, available attacks are worse. 

F Tier - Shuckle tier. 

Shuckle - Starts with three garbage moves and Wrap. Curl upgraded is okay. Its best ATK move is Headbutt but Shell Smash gives headbutt +2 damage. Resistance is a terrible stat. I got an early x-attack and that wasn't enough. The only pokemon I couldn't win with. 

Fun game. Kinda unbalanced though. 

Marill and Cacnea are very strong and heals are overpowered. I beat Marill with no upgrades first try. You outheal any damage you take. The shell bell is great for that reason, but it's much harder to complete a run without any source of heals. 

Every single run that I've won - 6 so far - has been because of the teeth item which costs 90ish and can give that much money in a single fight. It is by far the most important item. 

The other items that make runs a lot easier are shell bell, x-items, and pure stat boosting items. Crit is the only buff that matters - I had a croagunk run with all poison items and upgraded moves and it still didn't deal any damage. The cubone debuff is also trash. The best build is pure damage and heals, and crits if possible. 

I also have no idea how to evolve pokemon. I got Raichu by thunder stone and got Marowak and Cacturn somewhere along the way, but I have completed runs on other pokemon that didn't evolve.