Regarding this note in the game description: "IMPORTANT NOTE: This game is currently incompatible with MacOS Catalina and later versions. Sorry for the inconvenience."
You actually CAN run it on Catalina or later, I ran it on Ventura on M1 Mac. It wouldn't work straight away but popped up that the application could not be opened.
I had to right click the .app bundle, choose "Show Package Files", open "Contents", then MacOS, so that I could see the file "Midnight Scenes The Highway" (which is the actual executable inside the .app bundle) and then opened a terminal window.
Typed "chmod +x " then dragged the "Midnight Scenes The Highway" file to the terminal window and ran the command. After that it worked. I had already renamed the app bundle from "_BUILDS.app" to "Midnight Scenes The Highway.app" first and had placed it in my Applications folder already, so my command looked like:
chmod +x /Applications/Midnight\ Scenes\ The\ Highway.app/Contents/MacOS/Midnight\ Scenes\ The\ Highway
This just means that the actual executable file inside the .app bundle has not had its executable bit set and so the system refuses to attempt to run it until you correct that with a command like the above (obviously with whatever the correct path is for you and where you put the app bundle).
After doing this (and telling the security system that it's ok to run the app that was downloaded from the web) it ran just fine.
Dev can probably just do this to the .app themselves and reupload the zip and it should work, though it should be noted that if the zip file was created improperly it may have been the source of the permission error.