Sure! In the Training Grounds, on the screen to select a tier, the "Begin Challenge" button is only available in fullscreen mode, or it will be completely hidden.
In the Disciple Room (and similar rooms), the Condensation Chamber has the same problem; the "Condensate" button is barely visible, and there is no scrollbar to make it fully accessible.
I also remember the same thing happening during the last breakthrough when entering Core Formation, but it's been a while, so better to confirm it >_<