Sorry to copy/paste from the other reply, but I don't know if me replying to the original comment would send you a notification or not x3
Have you tried anything from this post yet?
https://melancholy-marionette.itch.io/darling-duality-winter-wish/devlog/227880/...
The link is to a different project of mine, but I put the same link on all my game pages cos, unfortunately, it seems like opening on Mac is a pain in the butt :( haha.
I don't own a Mac myself, so can't test anything >.< The guide is made up of info from folks with Macs who managed to get stuff working x3
The most common solution appears to be to always download itch games through the itch launcher and launch through that.
I think it's like a Mac security issue thing. The system tries to protect against unsigned software, but most indie games aren't signed or something. It's all too confusing for me to understand, haha.
I hope something from the list helps at least :3