As long as you are on a PC and have the proper runtime for RPG Maker VX Ace installed(which you can get for free from the RPG Maker website) you should be good to go to run the game once you start the application.
Recent community posts
Unfortunately I don't think that's possible with RPG Maker VX Ace games. You could maybe try this? http://blog.rpgmakerweb.com/tips-and-tricks/rpg-maker-on-your-mac/
My next game is being made in RPG Maker MV which I think should run fine on MAC though.
I love your art style in this! I bought the recent Humble Bundle with this included and I'm having some trouble figuring out which files go into which tile slots in RPG Maker MV. Do you have any kind of guide for getting this to work properly in MV?