Okayyy after reading what other people already told you, to not repeat feedback basically ;-;. I can say that the items in the middle of a run you don't really know what they do? A small description or similar would be nice. Plus, I had to touch my keyboard randomly to actually be able to use the actives, which u know, weird. Finally, I do think you will probably add this on the future, but for what I've played you can have two passives and 3 usables? Or thats what I believe. A little more of randomness on what you can carry would be nice (even if its just like nuclear throne and are passives after killing x enemies; I just think all runs are going to end up looking really similar if you can carry only that).
However, the animations/sprites are super coollll, the game already has "the sauce" and its in an early state, congrats for that. Combat is really nice too :D