Thank you so much @TrampolineTales for your work on making this accessible with a screenreader!
If I'm understanding this correctly, right now it's unfortunately unclear to a screenreader user how exactly the symbols are laid out, since arrowing around skips empty spots. So until all the symbols are filled, the exact lining up of the symbols is impossible to tell.
Would you maybe consider adding a gameplay option to allow the arrow keys to focus empty spots, and/or have the clipboard text reflect the focused position (e.g. "Pearl Common Gives Coin 1 Pearl row 1 column 4" or even just " 1 4")? I think having either one (or ideally both) of these would pretty much make this as playable as it gets.
Thanks again!