Very cool game. UI is pretty readable. I ran into a few bugs:
-After buying a rune from the shop, you become unable to place a rune modifier from the shop. Reloading from the main menu fixes this.
-Placing a frosty tile after reloading placed two tiles next to each other. I was trying to place the tile before exiting but ran into the bug I listed above where it wouldn't place; I'm unsure if that affected this.
-I was unable to leave the shop for some reason. The "leave shop" button was grayed out. Reloading the game from the main menu also fixed this. I wasn't able to find what caused it.
-Returning to the main menu, continuing, restarting from the pause menu, returning to the main menu a second time and continuing again reloads the first save instead of the restarted one.
-Clicking the draw pile more than once continues to add the draw pile into the scrolling menu. That popout menu could maybe also use a touchup since the scroll bar looks a bit messy.
The buzzword system is a cool idea, but it feels pretty luck-dependent and it's not immediately evident what getting them gives you. I would say maybe add a tooltip to them to make the effect clearer. It feels very luck-dependent, so it'd be a good idea to have some kind of logic under the hood to ensure that hyper-optimal play doesn't end up being to restart until you get good buzzwords. You might already have something like that going on; I didn't really dig into if there were any patterns. A way to reroll them might also help.
For item descriptions, I think a highlighting system for keywords with hover would go a long way, i.e. for something like Dracula, maybe highlight the keyword "Double Word Space" and then let you maybe right click it to highlight the ones on the board, or for something like Metamorphosis, to be able to hover over "Special Space" as a keyword to see what the options are. I'm sure something like that isn't top priority, but it would add a lot of readability.
I think gameplay-wise that it's in a pretty good place. With a little bit of polish and some more visual variety, this could end up REALLY good. The pieces all falling off the board after a game over is a great touch. Nice job.
