Also experiencing this issue. Made a Github issue here, here's the report:
(I'm using firefox 89.0 on linux, but it probably shouldn't matter)
Steps to reproduce:
1. enter any area marked "Subterrane" on the map, up to and including the bit where you have to help Alraune's sprout.
2. make sure you have ANY item selected
3. press enter to use the item
Expected behaviour: some text appears telling you what the item did, and, if applicable, there is some effect on the world
Actual behaviour: nothing happens - not even flavour text
thanks for the cute game!