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You'll have to run it from the command line. Open up Terminal and change to the directory where the app bundle is, then run this command:
open ./NoMariosSky.app --args -resetPrefs
We'll add a reset button to the title screen soon!
If you have an Nvidia GPU and you're not using the Nvidia binary Linux drivers, try switching to them. The Mesa Nouveau drivers (which is probably what you're on) can be unstable and out of date.
We just noticed some crazy behaviour in low quality where the game runs way too fast. But it might be ok for you if your machine isn't very high spec. We'll be pushing out an update tomorrow to fix that.