Most frameworks have some form of class that lets you handle spritesheets with methods for displaying the needed frames and thus animations.
For example in python & pygame: https://www.pygame.org/wiki/Spritesheet
In Godot you use a Sprite2D Node and a AnimationPlayer node to use sprite sheets directly.
In Rust and Bevy you load in your sprite sheet and then layout it: https://bevy.org/examples/2d-rendering/sprite-sheet/
let texture = asset_server.load("textures/rpg/chars/gabe/gabe-idle-run.png");
let layout = TextureAtlasLayout::from_grid(UVec2::splat(24), 7, 1, None, None);
let texture_atlas_layout = texture_atlas_layouts.add(layout);
let animation_indices = AnimationIndices { first: 1, last: 6 };