Make sure you're using glowplant fruit, and infections go down quite quickly if you keep a very close eye on them. Also, Disinfect before you go to sleep! being clean and well fed will also help.
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Yeah, my 2nd "death" (i got last stand and survived) was because i was stuck in a hole with only 2 tiles of dry land, and kept falling asleep into the water, and i slowly froze and drowned... Also, lumalgae says "inedible", but going from a bit depressed to killing yourself in that time period does seem a tiny bit unfair. even more if you were not even that sad before.
Don't worry! the last stand (second chance) takes mood from 10 Minutes ago, so you should still have a good chance. I tested the mood with commands, and you only lose 20-30 mood within the first 30 seconds of steeping on spike trap. Though, if it hits your head, it can be -50 mood loss (or more) because of trauma from losing your jaw / eye. Opioids are also great to use after a injury that makes you depressed or in severe pain.