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You don't even need to save at the start.  I saved right after grabbing the access key, and the fight became unwinnable (I swear I hit it at least 50 times). Deciding to see if letting it hit me so I'd lose, I went through all that and returned to the room, and it doesn't matter how many times I hit it, I still can't win.

That doesn't sound normal indeed, but I would need to take a look at your save to see if there's any issue. You can mail it to me if you'd like to.