If the problem is that you're getting ganged up on then try to take the enemies out one by one and don't get cocky. Otherwise:

Utilize the warning lines before an enemy attacks to know when to dodge.

Maintain high Willpower to reduce the chance of an enemy applying bondage.

Use any armor that you come across as enemies will usually (with little exceptions) need to remove it before applying and restraints.

Also, try to play to each class' strengths: 

Going for the Fighter class can help if you are decent enough at melee combat as the dodge and accuracy buffs from Battle Rhythm as well as the high Willpower are very helpful for resisting enemies.

Or, you could just go Wizard with Ice and Water/ Water and Lightning spells as those can shred enemies and allow you to keep your distance.

Its a game about bondage so its pretty hard to avoid :)