So what's the problem, that you click on different things than your mouse is hoveirng over or that the movement in game is smooth? Because the first one is probably caused by your screen ratio (which is 4:3 and VotV is designed for 16:9, I have the same problem on 21:9). If the second one, do as Suhanidze wrote
And please make recordings with the cursor visible so its easier to figure out how to help you, thx.