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First find the file you want to run in the browser, launch it to get the "defragmented file" error.
Reset the machine.
Now open the "Command Line".
Type "LS" to list the files. You should be in the same file location when you reset.

Find and note the NEX file (Next executable)

You will see the "ATICATAC.NEX" file you tried to run earlier (this example).

Now type ".DEFRAG ATICATAC.NEX" (This example) it takes a while, but that is the nature of the beast.

Thanks for this info, made it very easy to understand ;-)