I don't want to dive too much into speculation land, but I have some ideas.
1. I agree that the next game will likely be in one of the towers since the quest in this game was to gain access to a tower. For the enemy type? Could be Dobermans since we see them slumming in the gutter in GT, but I could easily see bitshift going in a different direction. Each game has its own color too, neon pink for CS and neon green for GT. I don't know what to expect in the next game, but maybe neon blue for the tower.
2. We know there is a mastermind behind the events in the first two games, having provided the ear clips to Diezel and probably the Dragon's Breath to Mahir (this is not explicitly stated, but the Dragon's Breath is a new development for the hyenas so it's likely they got it from the same source since Mahir is a cat's paw for the mastermind).
3. I'd wager that Scratch is also a (likely unwitting) cat's paw for the mastermind since it's through him that Mezz gets sent to both the island and the gutter which were both set-ups.
4. We don't know what the mastermind's goals are, but we know they have some mind control power at their disposal, at least enough to control Mahir. The mastermind is a 'fan' of Mezz, but we don't know what that means and whether messing with our protagonist is a primary or secondary objective.
I have some other much more speculative ideas about what's actually going on, but they have limited support from the actual text, so I am reluctant to share them just yet, we are only on game 2 of a planned 5 so it's still really early in the story.