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How do you save file on Mac?  When I click on save and then click on file 1 nothing happens.

you start at the game menu, on a pc you use esc, assume its the same on a mac but have not had a chance to test.  From this menu click Save.

This brings up the save slot menu

pick a slot


Then after click the slot, you have to click save again from the top menu. 

Hope this helps.