Considering no renpy game works on your pc, there could be an issue with either your Windows or with your software/drivers.
Maybe you have 32bit windows and trying to launch a 64bit exe-launcher. Maybe you have a Windows XP and Ren'Py just doesn't support your OS anymore. Maybe you don't have OpenGL and DirectX installed. Maybe the folder you are launching the game from has some read-only restrictions on it. Maybe your antivirus blocks the launch of Ren'Py for whatever reason.
The things above are the first that came to mind, so it's likely your issue isn't present there, but it's worth a try.