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I 100% agree first biome is for accumulating that cash money. I try to avoid dropping a checkpoint seed at all, I'm that greedy.

Second biome is where I try to build up half cash, half hearts. I try to have at least six hearts and twenty crystals by the end of the third biome.

I try to have at least one seed that does up-close combat well (knight seed, hot rolling rock) and one that handles projectiles well (reflect, shield). Possibly a third seed for dealing with the third biome's projectile hell (slow motion, invisibility). I'm keen on the star seed now too, as that one is super useful in the fourth biome and the final battle. Really lets you focus on moving upward without worrying about all the other chaos happening around you, and with enough time put into the game, you can make a ton of progress in that short star seed window.

Hole filler is huge in the fourth biome. It'd probably make the final battle easier, too, though I used a star seed to rush through that.

I think generally my strategy depends on what I'm given, and I try to buy what I didn't get for free.

So far I try to use the bank in the first camp. I'm still avoiding minigames for health reasons but I'll get back to them soon enough. Extra crystals would be great.

But at this point I feel like I'm mostly relying on luck to give me good seeds for free. The enemies and projectiles are tricky, but I love the increased hole density, since it's difficult but rarely feels cheap (the way being overwhelmed by too many enemies or bullets can feel cheap).

But to summarize my priorities are, in this order:

  1. Get money
  2. Get hearts
  3. Get the right offensive seeds (knight, hot rock)
  4. Get the right defensive seeds (shield, reflect, star, hole filler), ideally before the third biome