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It happened twice though, and the second time I knew what everything did and got damage upgrades as fast as I could

Myeaaah, sorry. What I said is the only solution to the problem I know. This game is really not well stitched together and there will sadly be no fix to this issue 

(+1)

You know what they say - if you can't beat it, turn it into a feature.

In this case, I think it would be that once you defeat that red tentacle guy at the end, the game automatically resets with a higher difficulty, sending you to a new "level" and restoring the spawn rates of the others.