Pickup range is way to tiny. And with the speed of scaling, anything but Damage pickups become useless, as you immediately loose the required power to make it through the Enemies fast enough if you pick up one of them. Not to mention stuff like HPregen, or increased pickup range do either nothing or way too little. Duration for Attack increase also seems completely useless, as no Attack I found had any duration at all. Unless you mean range, at which Point it only affects the Sword, and is also way too weak. Overall, the only Powerups I could really recognize when picked up were the clone, the Sword, Staff, Missile, and other Weapons, Zaps, Crits, Damage increase and size increase. Every other Powerup wasn't really felt, and Staff, Missiles, Zap, Crit only at the first time picking it up.
I'd actually prefer if it was all on autocast aswell, since holding down the Mouse constantly gets annoying, and there is never a reason to not constantly attack. The Aiming is fine tho.
I find the moving Floor annoying, it forces me to make sure I kill enemies at the top half, so I have time to bait the Horde away before rushing to the bottom half of the Screen trying not to miss any Pickups. And if you do miss enough, which very easily happens due to constantly having to avoid Hordes from everywhere, while making sure not to kill them, so you can then bring them back up top to kill them there, so you even have a chance for Pickups, and rushing to the bottom of the Screen to try and catch any Orbs you've missed, you immediately loose in the scaling race of your Damage. But instead of just loosing then, you have to very slowly run around, avoiding attacks while now being unable to actually kill anything, which just spirals you down further, until you eventually can't go anymore.