Yes, I've played Stellaris, CIV V, VI, XCOM 2, FC4, etc on this machine without problem.
I managed to find a workaround, but it's a bit weird so this might get confusing. My motherboard has a built in 3.5mm output, I'll refer to this as "Headphones" as that's what Windows recognizes it in the Playback Devices manager.
If I enable that device and plug something in, and then in the right-click menu for that device "Test" it, I can start the game and get audio through the DAC. If I don't run the "Test" immediately before starting the game I won't get audio. Restarting the game results in no audio, but running the sound test again and re-starting the game works.
Setting the Headphones device as the default and using it for audio also works as expected.
I'll do a bit more testing later, but right now I have game audio and want to play through a mission while it's working right.