Excellent game, I'm looking forward to more updates.
I've managed a successful win twice so far (in v 0.5) - my first win was super lucky. I got an early hell portal / hell hound / demon slayer combo; also managed to use Internal Affairs & a Trash Collector to clean up the other stuff in that run - that build Just Works (tm) - if you can get lucky enough to get it.
My second win was super save-scummy. Got a Paramedic, then a Siren, then got a Mad Scientist & save-scummed the Mad Scientist deployments until I got 2nd Paramedic & a Tax Accountant (also a couple Thieves & others, but the Tax Accountant is what actually matters); then I save-scummed every deployment to make sure the Tax Accountant stayed in range of the Paramedics so it didn't destroy itself, just kept ramping everything up. I did mess up towards the end & lost the Tax Accountant, but I had enough damage that I was able to finish the win (w/ a few more save-scums to make Pacifist trigger blocking damage).
Anyone have any other successful winning builds? I also had a good grey goo + gold goo run, but I didn't get it going early enough, so I died on the 2nd to last boss.