The current version of the game is running Ren'Py version 7.4 which uses Python version 2.7. Python v2.7 has reached end-of-life which may be why some Win10/11 machines have issues running it.
The next version of the game has already been ported over into the most recent version of Ren'Py 8.0+ and is now using Python 3. So in the next release this issue should resolve itself if you wish to wait.
In the interim, if you are still having issues you can try running the game in compatibility mode and/or check to see if you have any 3rd party antivirus software accidentally blocking it since it is technically using an unsupported version of Python.