Not much, I'd say it runs on anything.
If the game crashes or lags it might be because of basic problems like insufficient space, outdated drivers and whatnot.
In almost all cases it has to do with a video card obsolescence issue, your video card and/or its drivers are too old for Ren'py to use or simply not recognized. A solution would probably be to create the following file in a notepad:
define config.gl2 = False
And save it in the game map as .rpy
I would start by updating your drivers though, sorry I can't be of much more help.