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I know this is a prototype, but I think your name could be more expressive of the content I'm going to experience.  Names are an essential way we interact with media, and coming up with even a functional name ("Hide From The Pill Monster") is valuable design work, which will give your audience a good idea of what you're trying to convey, and internally give you a way of referring to the game without "ownership" - "this is XX's prototype".  I'd challenge you to come up with a more creative name that just a functional one. 

This core idea is very solid, but I agree that your creative challenge asks for an interrelation between the various things you're using in your game.  I think picking three primary colors and using any colors that are between them uses up all of the constituent colors, for example, or restoring one color means giving up some of a different color, etc., etc..