Thank you for your kind words. There will be other storylines in the future, stay tuned.
Unfortunately, that drug is only used by Max's boss organization, and you can only fight him directly at JCS storyline... but we'll have a gang storyline, and since Max boss won't be dealt away directly on the other storylines, his drug will make another appearance annoying you to no end.
I never thought about the stepdad thing with Luke... but nah, too complicated, it happens too late in the story and you know what kink I'm skipping on purpose here.