IIRC, I saw this stuff asked about in the discord. If I'm remembering correctly, Thresh said he had (at that time) no plans to have perma losses or enslavements (no "bad ends") that would require reloading entirely to escape. Even Kotone can be removed if you are heartless enough to go through her story and then say fuck off. This is meant to be more light-hearted and "free love" rather than perma enslavements. There may be modders who could/would create this, look for them.