I am sorry for the issue. Yes, you have to let her go in the den.
Here is the common instruction:
After Catching a skunk(girl), you can press 1 to relase it and 3 for carrying it.
you need to carry the skunk into your den to tame it. the interactions only works for tamed skunks.
you have to release the skunk in your den by pressing 1 again.
now you can choose any intercation with q.
you can start the interaction by pressing e on the skunk!
to stop the interaction you have to press e again.
After that you can change your Option.
let me know if you are still having the problem