I've got an Assassin Dagger with 23 golden whetstones, and 16 rage on it, with 12 Pavises around 6 ducttapes attached and my dagger doing 16592 damage, I'm on floor 358 still going strong, was forced to pick up 2 red hoods, 3 Dodge masks a regen whetstone, and a poison ivy to gain max health as curses started doing 600+hp and i needed health, the builds you can do in this game man, they are awesome but you just dont have a way to survive after the dudes start doing 300 above your max health.
the higher floors are crazy but its so rng, I've never played a game where you can go through 30 floors and there is only one item your looking for and all you do is check how much health have i gained or how much damage does my weapon do now? Its rather busted but hilarious.
Sables are the bane of my existence though, what enemy does 2,107 damage in one turn? now that is stupid man.