it shouldn't effect it but I will jot down to test the portable specific files, btw I would suggest the installer version anyway its just a nicer experience to be able to launch the game from the program files area, also at a much later time I hope, you can quiet easily uninstall the game via the uninstall programs system in Windows which means you don't have to remember which folder you put it in.
This feedback is very useful as I would like to get to the root of your issue.