The only reason you're dying is because you haven't gotten a good enough build yet. For the enemies with spikes, there is a relic "Cleansing Candle" that removes spikes when you attack. 50 armor is not enough. With items like archangel armor, the forge event which adds haste onto shields, or the item "Pretty Anklet", you can get haste which with structures or helmets, can get to the 999 block cap, although poison will kill you if you only block. With Assasin's Dagger, which gets one extra damage per kill, you can get to floor 100 and theoretically get to any floor you want.