Best tip I could give you is that you have to make sure you have a key in the crypt finale boss room and open the locked door after killing the boss. It will help you skip deep cave and let you go to enchanted swamp. I hope this message helps.
(after you open the door go to the exit behind the open door.)
Enchanted swamp is veeeeeery veeery bad against thorns builds and sustain builds. In my 200+ floor I went there once and almost killed my run, because the boss was hit by a single hit of my multi hit chain, while he summons 3 minions every turn.
IMPOSSIBLE to deal with with many many builds, other path is much more straight forward in general.