I manage to make the arguably the worst relic work.
that bomb breaks every weapon. But this staff recreate it's self. So it now only goat mana to support it's self and get a 500% multiplier. This shield relic let me use the staff sword at the cost of losing 1 damage permanently. But I just get new swords.
double angle armor lets me ramp armor so it ends up with me dealing 500 damage and 500 armor per turn...
Then I die to poison.