after this Floor 18 Grandmaster ended my run because of Burning damage. In my defense he was down to 3k, and the wand was doing around 320 a hit at the end.
60 max health, 20 passive block a turn, 13 mana generation a turn (after turn 1), 44 Mana turn 1 (32 starting +5 uses of the Tome for 2 each)