Locked nameless choices have a designed screen, like when you choose between encourage or discourage Logan, or is better to save the persistent file every time?
Not necessary, in other case (normal/bottom Logan, good/bad ending in ruin etc.) you can change you choice by reload your previous save. But in Nameless case, you can't.
I know but before you make important choice there is a big statement like "this choice may affect the future" or something like that whit nameless i'm at the fourth nighmare and nothing like that happened yet