As a guitarist myself, I appreciate this piece and its qualities. I'm trying to imagine a scenario where this would fit as a villain theme, but it's quite difficult to imagine. There are some notes that have a dissonance quality (I think the use of chromaticisms is what I'm thinking of) to it that I think has a more "mysterious sound", but I would say nothing sinister. I think this would fit well in a silent mono-chromatic short film.