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I mean, pretty much every resource but your own time and guild reputation is pointless (and even that loses it's use for most of them after a while), and you are even rewarded for just letting time fly by. There is no point to doing any slave request as you can always just skip a week ahead and re-roll the requests. 

That being said, a big buff to reputation or rare resources (things you can't just farm, like mythic leather or monster drops) for these quests would be way better than any gold increase.

Letting the timer go after the loan has been resolved is okay .  Getting the Notice Board missions done is far more important when you want to stop the loan  officers from dinging your bank account.

(And yes, you only have to get 3  of the 4 guilds done to stop  the loan but there' s a hidden bonus +5 stat necklace if you get the approval of all four.)

Oh, neat. I assume that's skipped if you go with advanced start?

If the advanced start doesn't give you the necklace, well, I don't know of any way other way to get it than by getting 4/3 on the part you just skipped.

I  suspect that it's lost.