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Are you using custom items? If so, your items could be too high poly and are pulling your system to it's knees. If you're using the default items, unless you have a very slow CPU, you should be fine. Could you please state your CPU, RAM and Graphics card?

All default items. 32 GB of RAM, GTX 1070 Ti graphics card, AMD Ryzen 7 3700X processor.

Prior to being forced to reinstall Windows, this system had zero issue with a large amount of items.

Maybe set the priority of VTuber Plus to hight? Also make sure to install the latest graphic driver.

I've already installed the graphics drivers I used prior to the reinstall and I've tested changing the program's priority, no difference. Also changed render quality and such in the program to no avail.

Unless there's some obscure setting or driver I'm missing somewhere, this isn't making any sense...it worked perfectly fine before, so why not now?